How to Avoid Atypical Depression

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a short haired woman in white tank top with her hand on her face

I won’t lie to you, I was more in a typical depression than an atypical depression when I was struck with depression. Although, I did have hypersomnia, and sensitivity to rejection. I believe the rejection stemmed from my trauma from childhood.

I still have problems with rejection, but I’ve learned to accept it better. It’s been difficult because of being a people pleaser. I felt like others rejected me as a whole person, rather than just my ideas.

Atypical depression meaning is a subtype of major depressive disorder (MDD) with unique symptoms distinguishing it from “typical” depression. Despite its name, atypical depression is not rare—it simply refers to a pattern of symptoms that differ from the classic presentation of depression. 

The difference between typical and atypical depression lies in their symptoms and how individuals respond to certain situations. Here’s a breakdown:

  • Core Symptoms: Persistent sadness, loss of interest or pleasure in activities (anhedonia), fatigue, feelings of worthlessness, and difficulty concentrating.
  • Physical Symptoms: Insomnia or hypersomnia, appetite changes (usually loss of appetite), and weight loss.
  • Mood Reactivity: Mood generally remains low and does not improve significantly in response to positive events.
  • Energy Levels: Often marked by low energy and lethargy.
  • Other Features: May include suicidal thoughts or feelings of hopelessness.
  • Core Symptoms: Shares many symptoms with typical depression, but has distinct features.
  • Mood Reactivity: A key difference is that mood can temporarily improve in response to positive events.
  • Physical Symptoms: Increased appetite (often leading to weight gain) and excessive sleep (hypersomnia).
  • Energy Levels: A heavy, leaden feeling in the arms or legs (leaden paralysis) is common.
  • Sensitivity: Heightened sensitivity to rejection or criticism, which can significantly impact relationships and self-esteem.
  • Social withdrawal: The act of avoiding or reducing interactions with others, often leading to isolation from friends, family, and social activities. 

The term “atypical” doesn’t mean it’s uncommon; it simply means it shows up differently than the “typical” signs of depression. The good news is that atypical depression often responds better to specific treatments, like monoamine oxidase inhibitors (MAOIs), than typical depression does.

Accordingly, atypical depression, like other types of depression, can have many causes that vary from person to person. It’s usually a mix of biological, psychological, and environmental factors working together. Here are some common causes and contributing factors:


When brain chemicals like serotonin, dopamine, and norepinephrine are out of balance, it can shake things up and impact your mood and emotional well-being. These imbalances are often linked to depression because they help with things like staying motivated, feeling good about accomplishments, and managing stress.

A family history of depression or mood disorders increases the risk of developing atypical depression, as both genetic and environmental factors influence mental health. Individuals with close relatives who have experienced depression may be more likely to develop the condition due to inherited traits or shared experiences affecting emotional well-being.


Basically, certain personality traits, like sensitivity to rejection, perfectionism, and low self-esteem, can make individuals more vulnerable to atypical depression. These traits often heighten emotional distress, create unrealistic expectations, and amplify negative thoughts, increasing the likelihood of developing depressive symptoms.

Poor coping skills for managing stress, trauma, or life challenges can significantly increase a person’s vulnerability to emotional, mental, and even physical health issues. Without healthy ways to process and respond, these difficulties can lead to feelings of being overwhelmed, anxious, or stuck, making it harder to navigate life’s obstacles effectively.


Prolonged stress from work, finances, or caregiving can harm mental health, leading to exhaustion, helplessness, and decreased emotional resilience. Over time, it may disrupt sleep, appetite, and overall well-being, making daily life harder to manage.

Going through difficult experiences like physical, emotional, or sexual abuse, neglect, bullying, or witnessing violence can take a serious toll on mental health and increase the risk of depression. These challenges can leave lasting emotional impacts, make it harder to manage stress, and sometimes lead to feelings of hopelessness or despair. But understanding these effects is the first step toward healing and finding support.

Lacking strong social connections can make loneliness harder to handle, leaving people feeling isolated. Without meaningful relationships, sensitivity to rejection can increase, making small criticisms or exclusions feel bigger than they are. Therefore, this can create a cycle that makes emotional challenges even harder to manage.

Big life changes—like losing a loved one, going through a divorce, or moving to a new place—can be tough emotional triggers. These moments often shake up our routines, challenge our sense of stability, and bring feelings of uncertainty, making them especially tricky to handle.


In general, atypical depression is often linked to feeling extra sensitive to rejection or criticism. This sensitivity can come from past experiences like bullying, neglect, or challenging relationships, which influence how people see and react to social situations.

While it’s not always possible to completely prevent atypical depression (or any form of depression), there are steps you can take to reduce your risk and promote mental well-being. Here are some strategies:

Physical activity boosts endorphins and serotonin, which can improve mood and reduce stress.

Eat a diet rich in whole foods, including fruits, vegetables, lean proteins, and healthy fats. Avoid excessive sugar and processed foods, which can negatively impact mood.

Aim for 7-9 hours of quality sleep each night to support your health. Stick to a consistent sleep schedule, going to bed and waking up at the same time daily, even on weekends. Create a calming bedtime routine, like dimming the lights, reading, or practicing relaxation, to help your body wind down for restful sleep.

woman sitting while looking lonely

Additionally, practices like mindfulness, yoga, or deep breathing can help you manage stress and stay grounded by promoting relaxation and creating a sense of balance. Mindfulness encourages you to focus on the present moment. Yoga combines physical movement with mental clarity, and deep breathing slows your heart rate and calms your mind.

Engage in activities that help you unwind, such as reading, listening to music, or spending time in nature.

Maintain close relationships with friends and family. Hence, social support is a protective factor against depression.

Also, participate in groups or activities that align with your interests to foster a sense of belonging.

Consider seeing a therapist or counselor, even if you’re not currently experiencing symptoms. Therapy can help you develop coping skills and address underlying issues.

Writing about your thoughts and feelings can help you process emotions and identify patterns.

Be kind to yourself and don’t be too hard when things don’t go perfectly. Everyone makes mistakes and faces challenges—it’s just part of growing! Try to treat yourself the way you’d treat a good friend, with compassion and understanding. Focus on what you can learn and grow, instead of getting stuck on what didn’t go right.

Take care of yourself by steering clear of toxic relationships or environments that bring stress, anxiety, or feelings of rejection. These situations can really affect your mental health and overall well-being. It’s so important to set boundaries and surround yourself with kind, supportive people who uplift and empower you!

  • Atypical Antidepressants:
    • Bupropion (Wellbutrin)
    • Mirtazapine (Remeron)
    • Nefazodone
    • Trazodone
    • Vilazodone (Viibryd)
    • Vortioxetine (Trintellix)
  • Monoamine Oxidase Inhibitors (MAOIs):
    • These are effective but require dietary restrictions to avoid interactions.
  • Selective Serotonin Reuptake Inhibitors (SSRIs):
    • Commonly prescribed options include fluoxetine, sertraline, and escitalopram.

a woman sitting at the table
Photo by Nataliya Vaitkevich on Pexels.com

CBT is a highly effective, evidence-based approach for treating depression, including atypical depression. It helps you recognize and change negative thought patterns and behaviors that may be contributing to your symptoms.

IPT helps improve interpersonal relationships and social skills, making it especially useful for people with atypical depression who might find it hard to deal with rejection or relationship challenges.

Basically, this therapy helps explore unconscious thoughts and past experiences that might contribute to current feelings of depression. It’s a great option for anyone looking to understand the deeper roots of their depression.

Atypical depression differs from typical depression. Symptoms include oversleeping, overeating, sensitivity to rejection, fatigue, and a heavy feeling in the limbs. Unlike typical depression, those with atypical depression can still feel moments of happiness or pleasure. The good news? It often responds well to certain medications, offering hope for effective treatment.

I know there isn’t just one cause of atypical depression—it’s probably a combination of genetic, biological, and environmental factors. Research shows that if depression runs in your family, you might be more likely to experience atypical depression.

I know there are many facets of depression, but I believe depression is depression. It’s easily to fall into a depression if you’re not careful. It’s also passed through genetics, like in my life. I don’t wish it upon my worst enemy. Peace and love. Until next time…



woman lying on a bed looking away
Photo by Darina Belonogova on Pexels.com

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● About Me

Hi, I’m Cindee, the creator and author behind one voice in the vastness of emotions. I’ve been dealing with depression and schizophrenia for three decades. I’ve been combating anxiety for ten years. Mental illnesses have such a stigma behind them that it gets frustrating. People believe that’s all you are, but you’re so much more. You can strive to be anything you want without limitations. So, be kind.