
Presently, what are the best anxiety, depression meds? I will list them below, shortly. Also, I will list some over the counter and some antidepressants that have no (or little) weight gain. I’ve also listed some side effects for most of the medications. I believe side effects are very important because you don’t want to feel any worse than you already feel. Right? Therefore, make sure you have good communication between you and your doctor.

Comparatively, I am taking Duloxetine (Cymbalta) for my depression and Hydroxyzine (Vistaril) for my anxiety. At the present time, they are working exceptionally well. Equally, there are minimal side effects to these meds. Hydroxyzine is normally used to put you to sleep right before surgery. Consequently, it can make you sleepy depending on the dosage you take. I take 50mg in the morning and 100mg at bedtime (to help me fall asleep).
“You’ve got to get up every morning with determination if you’re going to go to bed with satisfaction.”-George Lorimer
Best Antidepressants for Anxiety and Depression
Here are some of the best depression and anxiety medications:
Best SSRI for Anxiety and Depression
Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed antidepressants. They can ease symptoms of moderate to severe depression, are relatively safe and typically cause fewer side effects than other types of antidepressants do. The Food and Drug Administration (FDA) has approved these SSRIs to treat depression:
- Citalopram (Celexa)
- Escitalopram (Lexapro)
- Fluoxetine (Prozac)
- Paroxetine (Paxil, Pexeva)
- Sertraline (Zoloft)
In short, these are the possible side effects of SSRIs which may include, among others:
- Nausea, vomiting or diarrhea
- Headache
- Drowsiness
- Dry mouth
- Insomnia
- Nervousness, agitation or restlessness
- Dizziness
- Sexual problems, such as reduced sexual desire, difficulty reaching orgasm or inability to maintain an erection (erectile dysfunction)
- Impact on appetite, leading to weight loss or weight gain
Best SNRI for Anxiety and Depression
Additionally, here are some more best depression and anxiety medications:
Serotonin and norepinephrine reuptake inhibitors (SNRIs) are a class of medications that are effective in treating depression. Accordingly, SNRIs are also sometimes used to treat other conditions, such as anxiety disorders and long-term (chronic) pain. In The Food and Drug Administration (FDA) has approved these SNRIs to treat depression:
- Desvenlafaxine (Pristiq)
- Duloxetine (Cymbalta) — also approved to treat anxiety and certain types of chronic pain
- Levomilnacipran (Fetzima)
- Venlafaxine (Effexor XR) — also approved to treat certain anxiety disorders and panic disorder
Altogether, the most common possible side effects of SNRIs include:
- Nausea
- Dry mouth
- Dizziness
- Headache
- Excessive sweating
Additionally, other possible side effects may include:
- Tiredness
- Constipation
- Insomnia
- Changes in sexual function, such as reduced sexual desire, difficulty reaching orgasm or the inability to maintain an erection (erectile dysfunction)
- Loss of appetite
Best Antidepressant for Anxiety and Depression Without Weight Gain
Basically, like every other medication, antidepressants have side effects that affect some, but not all people. At length, one of the most notable is weight gain. Does weight gain happen with all antidepressants? No. And it doesn’t happen to everyone. How much weight gain is typical? Comparatively, a quarter of those who take antidepressants gain 10 pounds or more.

“When comparing all antidepressants, bupropion [Wellbutrin] is the least likely to cause weight gain and, in most cases, will be weight neutral or cause weight loss over time. Alternatively, mirtazapine [Remeron] is most widely implicated in weight gain as a side effect.” “Therefore, SSRIs as a class are all fairly comparable with regard to weight gain risk, with paroxetine [Paxil] being the most likely in this group,” Gable says, PharmD, BCPP, professor and director of Well-being and Resilience at SIUE School of Pharmacy and Psychiatric Pharmacist at Family Care Health Centers in St. Louis, MO.
“All the art of living lies in a fine mingling of letting go and holding on.”-Havelock Ellis
Over the Counter Anxiety Depression Medication
At this point, here are some the best OTC Anxiety, Depression Meds
- Antihistamines. Most often used to treat allergies, antihistamines typically cause side effects of drowsiness or sedation.
- 5-hydroxytryptophan (5-HTP) 5-HTP, sometimes called tryptophan, is a compound found naturally in the body.
- Magnesium.
- CBD.
- Ashwagandha.
- Kava.
- Valerian.
Regardless, if you try any of these and they don’t work, please go see your doctor. These are not substitutes for antidepressants. In my experience, the antidepressants work better, but I still wanted to list these.
“The price of anything is the amount of life you exchange for it.”-Henry David Thoreau
Conclusion
Therefore, there are lots of best meds to choose from for anxiety and depression. Especially those with low side effects and little to no weight gain. I’ve been on some meds that had horrible side effects, so I refused to take them. Consequently, the side effects were worse than the actual illness. Eventually, you have to speak up and tell the doctor that you can’t take the med they prescribed. Nonetheless, be an advocate for yourself if no one else will help you.
Well, it’s time for me to go again. I hope some of these meds will help you in the future or you are taking them and they are helping. At the same time, I will keep you up to date on any new meds that arrive. Live well, until next time…

Articles
-SNRI Drugs List: What to Know About Popular SNRIs Like Cymbalta
https://www.goodrx.com/classes/snris/snri-drugs-list
-SSRIs vs. SNRIs for Treating Anxiety
https://psychcentral.com/anxiety/ssris-vs-snris-for-treating-anxiety
-How to Evaluate the Pros and Cons of 6 Top Anxiety Medications
Have a Good One,
One Voice – Unstoppable
“It is better to fail in originality than to succeed in imitation.“-Herman Melville
Related Posts
Overcoming Social Anxiety(Opens in a new browser tab)
Major Depressive Disorder With Anxious Distress(Opens in a new browser tab)
Anxiety…Five Ways To Relieve Stress(Opens in a new browser tab)
Do Beta-Blockers Really Work For Anxiety?(Opens in a new browser tab)
Sources

https://khealth.com/learn/anxiety/over-the-counter-anxiety-medication/
https://www.webmd.com/depression/features/antidepressants-weight-gain
https://www.mayoclinic.org/diseases-conditions/depression/in-depth/antidepressants/art-20044970
https://www.mayoclinic.org/diseases-conditions/depression/in-depth/ssris/art-20044825S


Leave a Reply